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Klc1tm1Gsn
Targeted Allele Detail
Nomenclature
Symbol: Klc1tm1Gsn
Name: kinesin light chain 1; targeted mutation 1, Lawrence S B Goldstein
MGI ID: MGI:2136259
Gene: Klc1  Location: Chr12:111758849-111807844 bp, + strand  Genetic Position: Chr12, 61.13 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57877
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn IRES Beta-geo cassette replaced the exon that encodes the entire first TPR domain and part of the second TPR domain. Western analysis of crude cytoplasmic brain extracts of homozygous mutant mice detected dramatically reduced levels of full length KLC1, as well as very small amounts of truncated KLC1. Immunoprecipitation studies did not detect either form of KLC1 in KIF5A or KIF5B coprecipitates of brain extracts of homozygous mutant mice. Immunofluorescence studies of sensory and motor neuron cell bodies in dorsal root ganglion and spinal cord of homozygous mutant mice detected very faint KCL1 staining. (J:57877)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Klc1 Mutation:  32 strains or lines available
References
Original:  J:57877 Rahman A, et al., Defective kinesin heavy chain behavior in mouse kinesin light chain mutants. J Cell Biol. 1999 Sep 20;146(6):1277-88
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory