About   Help   FAQ
Targeted Allele Detail
Symbol: Fgfr3tm5.1Cxd
Name: fibroblast growth factor receptor 3; targeted mutation 5.1, Chu-Xia Deng
MGI ID: MGI:2135677
Synonyms: Fgfr3365
Gene: Fgfr3  Location: Chr5:33721674-33737067 bp, + strand  Genetic Position: Chr5, 17.83 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:67780
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Single point mutation
Mutation detailsA point mutation was introduced that altered codon 365 from one encoding serine to one encoding cysteine (S365C). A loxP flanked neomycin cassette inserted into an adjacent intron was removed via Cre mediated recombination in this derivative of Fgfr3tm5Cxd. (J:67780)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgfr3 Mutation:  29 strains or lines available
Original:  J:67780 Chen L, et al., A Ser(365)-->Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasia. Hum Mol Genet. 2001 Mar 1;10(5):457-65
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory