About   Help   FAQ
Targeted Allele Detail
Symbol: Fgfr3tm1Cxd
Name: fibroblast growth factor receptor 3; targeted mutation 1, Chu-Xia Deng
MGI ID: MGI:2135666
Synonyms: pFgfr3-TD
Gene: Fgfr3  Location: Chr5:33721674-33737067 bp, + strand  Genetic Position: Chr5, 17.83 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:52438
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted
Mutation:    Insertion
Mutation detailsKnock-in construct in which a portion of a cDNA corresponding to exons 5-19 followed by a polyadenylation signal was inserted into the endogenous locus. This allele carried a point mutation in codon 644 that altered the corresponding amino acid from lysine to glutamine. A loxP flanked neomycin cassette also inserted downstream of the inseted cDNA was removed via Cre mediated recombination in the final allele. (J:52438)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgfr3 Mutation:  29 strains or lines available
Original:  J:52438 Li C, et al., A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors. Hum Mol Genet. 1999 Jan;8(1):35-44
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.12
The Jackson Laboratory