About   Help   FAQ
Dcctm1Wbg
Targeted Allele Detail
Nomenclature
Symbol: Dcctm1Wbg
Name: deleted in colorectal carcinoma; targeted mutation 1, Robert A Weinberg
MGI ID: MGI:1934924
Synonyms: Dcc-, DccX3
Gene: Dcc  Location: Chr18:71258738-72351069 bp, - strand  Genetic Position: Chr18, 45.24 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:39765
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted into exon 3. Immunoprecipitation experiments demonstrated that no full length protein was produced from this allele in homozygous mice. (J:39765)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 12 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dcc Mutation:  38 strains or lines available
Notes
Homozygous mutant mice have defective axonal projections of neural cells similar to those observed in null mutations for the netrin gene, Ntn1, but with no effects on intestine or on tumorigenesis within the intestine (J:39765).
References
Original:  J:39765 Fazeli A, et al., Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. Nature. 1997 Apr 24;386(6627):796-804
All:  46 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/27/2016
MGI 6.05
The Jackson Laboratory