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Targeted Allele Detail
Symbol: Sgcatm1Kcam
Name: sarcoglycan, alpha (dystrophin-associated glycoprotein); targeted mutation 1, Kevin P Campbell
MGI ID: MGI:1934922
Synonyms: alphaSG-, KO/KO, Sgcanull, Sgcatm594Kcam
Gene: Sgca  Location: Chr11:94853617-94867153 bp, - strand  Genetic Position: Chr11, 59.01 cM, cytoband C
Sgcatm1Kcam/Sgcatm1Kcam mice display a progressive muscular dystrophy

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:49992
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsReplacement of 902 bp including exons 2 and 3 with a neomycin cassette. No mRNA was detectable in Northern blots of total RNA derived from skeletal muscle tissue of homozygous mutants, and no protein was detected in Western blots in membrane enriched preparations of skeletal muscle. (J:49992)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Sgca Mutation:  20 strains or lines available
Original:  J:49992 Duclos F, et al., Progressive muscular dystrophy in alpha-sarcoglycan-deficient mice. J Cell Biol. 1998 Sep 21;142(6):1461-71
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory