About   Help   FAQ
The MGI survey is now closed.
Thanks for your support!
Mgptm1Kry
Targeted Allele Detail
Nomenclature
Symbol: Mgptm1Kry
Name: matrix Gla protein; targeted mutation 1, Gerard Karsenty
MGI ID: MGI:1934912
Synonyms: MGP-, mgpm1
Gene: Mgp  Location: Chr6:136872436-136875805 bp, - strand  Genetic Position: Chr6, 66.72 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:38867
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a 3.4 kb fragment of the gene containing the proximal promoter, exons 1, 2, 3, and most of 4. Northern blots of RNA from lungs of homozygous mutant mice showed no detectable transcript for the targeted protein. (J:38867)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mgp Mutation:  1 strain or line available
References
Original:  J:38867 Luo G, et al., Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature. 1997 Mar 6;386(6620):78-81
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/20/2015
MGI 5.21
The Jackson Laboratory