Mgp^tm1Kry
Targeted Allele Detail

Summary

• Symbol: Mgp^tm1Kry
• Name: matrix Gla protein; targeted mutation 1, Gerard Karsenty
• MGI ID: MGI:1934912
• Synonyms: MGP-, mgp^m1
• Gene: Mgp Location: Chr6:136849433-136852821 bp, - strand Genetic Position: Chr6, 66.72 cM
• Alliance: Mgp^tm1Kry page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:38867
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a 3.4 kb fragment of the gene containing the proximal promoter, exons 1, 2, 3, and most of 4. Northern blots of RNA from lungs of homozygous mutant mice showed no detectable transcript for the targeted protein. (J:38867)

Expression

In Structures Affected by this Mutation:

21 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mgp Mutation: 10 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Singleton-Merten Syndrome in homozygous mice (J:38867)

References

• Original: J:38867 Luo G, et al., Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature. 1997 Mar 6;386(6620):78-81
• All: 29 reference(s)