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Targeted Allele Detail
Symbol: Mgptm1Kry
Name: matrix Gla protein; targeted mutation 1, Gerard Karsenty
MGI ID: MGI:1934912
Synonyms: MGP-, mgpm1
Gene: Mgp  Location: Chr6:136872435-136875823 bp, - strand  Genetic Position: Chr6, 66.72 cM
Germline Transmission:  Earliest citation of germline transmission: J:38867
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced a 3.4 kb fragment of the gene containing the proximal promoter, exons 1, 2, 3, and most of 4. Northern blots of RNA from lungs of homozygous mutant mice showed no detectable transcript for the targeted protein. (J:38867)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mgp Mutation:  5 strains or lines available
Phenotypic Similarity to Human Syndrome: Singleton-Merten Syndrome in homozygous mice (J:38867)
Original:  J:38867 Luo G, et al., Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature. 1997 Mar 6;386(6620):78-81
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory