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Col4a3tm1Jhm
Targeted Allele Detail
Nomenclature
Symbol: Col4a3tm1Jhm
Name: collagen, type IV, alpha 3; targeted mutation 1, Jeffrey H Miner
MGI ID: MGI:1934893
Synonyms: COL4A3-
Gene: Col4a3  Location: Chr1:82586921-82722059 bp, + strand  Genetic Position: Chr1, 42.32 cM
Kidney abnormalities in Col4a3tm1Jhm/Col4a3tm1Jhm mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:37017
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsReplacement of the first three coding exons with a neomycin cassette. No protein was detectable by immunohistochemical analysis on homozygous mice. (J:37017)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col4a3 Mutation:  41 strains or lines available
References
Original:  J:37017 Miner JH, et al., Molecular and functional defects in kidneys of mice lacking collagen alpha 3(IV): implications for Alport syndrome. J Cell Biol. 1996 Dec;135(5):1403-13
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory