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Hspg2tm1Ref
Targeted Allele Detail
Nomenclature
Symbol: Hspg2tm1Ref
Name: perlecan (heparan sulfate proteoglycan 2); targeted mutation 1, Reinhard Fassler
MGI ID: MGI:1934892
Gene: Hspg2  Location: Chr4:137468769-137570630 bp, + strand  Genetic Position: Chr4, 69.93 cM
Hemopericardium development in E10.5 Hspg2tm1Ref/Hspg2tm1Ref embryos

Show the 6 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:58700
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA neomycin/thymidine kinase cassette flanked by single loxP sites was inserted into intron 5 and a single loxP site was inserted into intron 6 of the gene. Correctly targeted ES cells were treated with cre recombinase and, in resultant clones, the sequence between the outermost loxP sites (including the neomycin/thymidine kinase cassette, part of intron 5, exon 6, and part of intron 6) was deleted. (J:58700)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hspg2 Mutation:  134 strains or lines available
References
Original:  J:58700 Costell M, et al., Perlecan maintains the integrity of cartilage and some basement membranes. J Cell Biol. 1999 Nov 29;147(5):1109-22
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory