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Targeted Allele Detail
Symbol: Socs2tm1Wehi
Name: suppressor of cytokine signaling 2; targeted mutation 1, Walter and Eliza Hall Institute of Medical Research
MGI ID: MGI:1934557
Synonyms: SOCS-2-
Gene: Socs2  Location: Chr10:95385362-95417180 bp, - strand  Genetic Position: Chr10, 49.35 cM
Germline Transmission:  Earliest citation of germline transmission: J:63006
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe entire coding region was replaced by a beta-gal-PGK-neomycin resistance cassette in which the beta-galactosidase coding region was fused to the initiation codon. Northern analysis of ten organs did not detect transcript in homozygous mice. (J:63006)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 16 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Socs2 Mutation:  10 strains or lines available
Original:  J:63006 Metcalf D, et al., Gigantism in mice lacking suppressor of cytokine signalling-2. Nature. 2000 Jun 29;405(6790):1069-73
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory