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Targeted Allele Detail
Symbol: Pax6tm2Pgr
Name: paired box 6; targeted mutation 2, Peter Gruss
MGI ID: MGI:1934348
Synonyms: Pax6flox, Pax6lox
Gene: Pax6  Location: Chr2:105668900-105697364 bp, + strand  Genetic Position: Chr2, 55.31 cM
Germline Transmission:  Earliest citation of germline transmission: J:65765
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsInsertion of loxP sequences flanking the exons encoding the amino terminus of the protein, including the initiator methionine and most of the paired domain. A frt-flanked neomycin cassette in intron 6 was removed via Flp-mediated recomination to create the final allele. These insertions had no effect on the normal function of the allele. (J:65765)
View phenotypes for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 8 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pax6 Mutation:  49 strains or lines available
Phenotypic Similarity to Human Syndrome: juvenile glaucoma in mice heterozygous for Pax6tm2Pgr and hemizygous for Tg(Pax6-cre,GFP)1Pgr (J:163191).

Original:  J:65765 Ashery-Padan R, et al., Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. Genes Dev. 2000 Nov 1;14(21):2701-11
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory