Pax6^tm2Pgr
Targeted Allele Detail

Summary

• Symbol: Pax6^tm2Pgr
• Name: paired box 6; targeted mutation 2, Peter Gruss
• MGI ID: MGI:1934348
• Synonyms: Pax6^flox, Pax6^lox
• Gene: Pax6 Location: Chr2:105499245-105527709 bp, + strand Genetic Position: Chr2, 55.31 cM
• Alliance: Pax6^tm2Pgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65765
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Insertion of loxP sequences flanking the exons encoding the amino terminus of the protein, including the initiator methionine and most of the paired domain. A frt-flanked neomycin cassette in intron 6 was removed via Flp-mediated recomination to create the final allele. These insertions had no effect on the normal function of the allele. (J:65765)

Disease models

Expression

In Mice Carrying this Mutation:	38 assay results 6 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pax6 Mutation: 90 strains or lines available

References

• Original: J:65765 Ashery-Padan R, et al., Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. Genes Dev. 2000 Nov 1;14(21):2701-11
• All: 40 reference(s)