About   Help   FAQ
Targeted Allele Detail
Symbol: Prnptm1Rcm
Name: prion protein; targeted mutation 1, Richard C Moore
MGI ID: MGI:1934273
Synonyms: Prnpa[108F189V], PrP gtB
Gene: Prnp  Location: Chr2:131909928-131938429 bp, + strand  Genetic Position: Chr2, 64.07 cM
Germline Transmission:  Earliest citation of germline transmission: J:45908
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted
Mutation:    Nucleotide substitutions
Mutation detailsThe 129P2/OlaHsd strain normally carries the PrP A allotype, with leucine and threonine at residues 108 and 189. In this allele, the sequences encoding these amino acids were altered to instead encode phenylalanine and valine. These changes alter the allotype to one identical to PrP B. (J:29021)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prnp Mutation:  95 strains or lines available
Original:  J:45908 Moore RC, et al., Mice with gene targetted prion protein alterations show that Prnp, Sinc and Prni are congruent [see comments]. Nat Genet. 1998 Feb;18(2):118-25
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.14
The Jackson Laboratory