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Trp63tm1Fmc
Targeted Allele Detail
Nomenclature
Symbol: Trp63tm1Fmc
Name: transformation related protein 63; targeted mutation 1, Frank McKeon
MGI ID: MGI:1934269
Synonyms: p63-, p63 KO, Tp63-
Gene: Trp63  Location: Chr16:25683763-25892102 bp, + strand  Genetic Position: Chr16, 17.37 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:54637
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 6, 7, 8, encoding sequences corresonding to the DNA-binding domain, and the intervening introns were replaced by a neomycin gene. (J:54637)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 44 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp63 Mutation:  29 strains or lines available
References
Original:  J:54637 Yang A, et al., p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature. 1999 Apr 22;398(6729):714-8
All:  33 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory