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Shhtm2Amc
Targeted Allele Detail
Nomenclature
Symbol: Shhtm2Amc
Name: sonic hedgehog; targeted mutation 2, Andrew P McMahon
MGI ID: MGI:1934268
Synonyms: Shhc, ShhC-NShh, ShhCo, Shhf, Shhflox, Shhflx, Shhlox
Gene: Shh  Location: Chr5:28456840-28467101 bp, - strand  Genetic Position: Chr5, 14.39 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65294
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsLoxP sites were inserted into intronic sequences flanking exon 2. This mutation has no effect on the normal function of this gene. (J:65294)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 121 assay results
In Structures Affected by this Mutation: 47 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Shh Mutation:  23 strains or lines available
References
Original:  J:65294 Dassule HR, et al., Sonic hedgehog regulates growth and morphogenesis of the tooth. Development. 2000 Nov;127(22):4775-85
All:  120 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory