Shh^tm2Amc
Targeted Allele Detail

Summary

• Symbol: Shh^tm2Amc
• Name: sonic hedgehog; targeted mutation 2, Andrew P McMahon
• MGI ID: MGI:1934268
• Synonyms: Shh^c, Shh^C-NShh, Shh^Co, Shh^f, Shh^flox, Shh^flx, Shh^lox
• Gene: Shh Location: Chr5:28661838-28672099 bp, - strand Genetic Position: Chr5, 14.39 cM
• Alliance: Shh^tm2Amc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65294
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted into intronic sequences flanking exon 2. This mutation has no effect on the normal function of this gene. (J:65294)

Expression

In Mice Carrying this Mutation:	157 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	47 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Shh^tm2Amc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Shh Mutation: 45 strains or lines available

References

• Original: J:65294 Dassule HR, et al., Sonic hedgehog regulates growth and morphogenesis of the tooth. Development. 2000 Nov;127(22):4775-85
• All: 140 reference(s)