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Shhtm1Amc
Targeted Allele Detail
Nomenclature
Symbol: Shhtm1Amc
Name: sonic hedgehog; targeted mutation 1, Andrew P McMahon
MGI ID: MGI:1934261
Synonyms: Shh-, Shhn
Gene: Shh  Location: Chr5:28456815-28467101 bp, - strand  Genetic Position: Chr5, 14.39 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:50050
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A neomycin cassette replaced exon 2 and portions of the flanking intronic sequences. (J:50050)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 124 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Shh Mutation:  22 strains or lines available
References
Original:  J:50050 St-Jacques B, et al., Sonic hedgehog signaling is essential for hair development. Curr Biol. 1998 Sep 24;8(19):1058-68
All:  60 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory