Dhh^tm1Amc
Targeted Allele Detail

Summary

• Symbol: Dhh^tm1Amc
• Name: desert hedgehog; targeted mutation 1, Andrew P McMahon
• MGI ID: MGI:1934259
• Synonyms: Dhh-
• Gene: Dhh Location: Chr15:98789033-98796421 bp, - strand Genetic Position: Chr15, 55.05 cM
• Alliance: Dhh^tm1Amc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57914
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1, 2 and part of 3 were replaced with a neomycin cassette. The deleted segments encode a conserved polypeptide required for protein function. Thus, no functional protein is predicted to be produced from this allele. (J:57914)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dhh Mutation: 23 strains or lines available

References

• Original: J:57914 Bitgood MJ, et al., Sertoli cell signaling by Desert hedgehog regulates the male germline. Curr Biol. 1996 Mar 1;6(3):298-304
• All: 20 reference(s)