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Ihhtm1Amc
Targeted Allele Detail
Nomenclature
Symbol: Ihhtm1Amc
Name: Indian hedgehog; targeted mutation 1, Andrew P McMahon
MGI ID: MGI:1934258
Synonyms: Ihh-, Ihhn
Gene: Ihh  Location: Chr1:74945315-74951672 bp, - strand  Genetic Position: Chr1, 38.55 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57297
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 156 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ihh Mutation:  3 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Hirschsprung disease in homozygous mice (J:62158)

References
Original:  J:57297 St-Jacques B, et al., Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation [published erratum appears in Genes Dev 1999 Oct 1;13(19):2617]. Genes Dev. 1999 Aug 15;13(16):2072-86
All:  36 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory