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Plaurtm1Mlg
Targeted Allele Detail
Nomenclature
Symbol: Plaurtm1Mlg
Name: plasminogen activator, urokinase receptor; targeted mutation 1, Richard C Mulligan
MGI ID: MGI:1934210
Synonyms: u-PAR -, uPAR-
Gene: Plaur  Location: Chr7:24462484-24475968 bp, + strand  Genetic Position: Chr7, 10.92 cM, cytoband A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:31253
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK- neomycin cassette replaced exons 2-5, resulting in the inactivation of both splice variants of the gene. The absence of protein was verified in an ELISA assay on culture from primary embryonic fibroblast cells. (J:31253)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plaur Mutation:  5 strains or lines available
References
Original:  J:31253 Dewerchin M, et al., Generation and characterization of urokinase receptor-deficient mice. J Clin Invest. 1996 Feb 1;97(3):870-8
All:  36 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/11/2017
MGI 6.08
The Jackson Laboratory