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Gfra1tm1Rosl
Targeted Allele Detail
Nomenclature
Symbol: Gfra1tm1Rosl
Name: glial cell line derived neurotrophic factor family receptor alpha 1; targeted mutation 1, Arnon Rosenthal
MGI ID: MGI:1934205
Synonyms: gfra1-
Gene: Gfra1  Location: Chr19:58235604-58455909 bp, - strand  Genetic Position: Chr19, 54.18 cM, cytoband D2-D3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:68750
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced part of exon 2, resulting in the deletion of amino acids 14 - 66. In situ hybridization using an exon 2-specific probe, showed no detectable transcripts in homozygous mutant mice. (J:68750)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gfra1 Mutation:  5 strains or lines available
References
Original:  J:68750 Cacalano G, et al., GFRalpha1 is an essential receptor component for GDNF in the developing nervous system and kidney. Neuron. 1998 Jul;21(1):53-62
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory