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Runx1tm1Sata
Targeted Allele Detail
Nomenclature
Symbol: Runx1tm1Sata
Name: runt related transcription factor 1; targeted mutation 1, Masanobu Satake
MGI ID: MGI:1934197
Synonyms: AML1(-)
Gene: Runx1  Location: Chr16:92601466-92826149 bp, - strand  Genetic Position: Chr16, 53.7 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:50937
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 4 was replaced by a PGK-neo cassette. The deleted region encoded the central portion of the conserved DNA-binding domain. Transcript was undetectable by RT-PCR analysis of extracts from the yolk sacs, livers, and aorta-mesonephros regions of homozygous mutant embryos. (J:50937)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 241 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Runx1 Mutation:  18 strains or lines available
References
Original:  J:50937 Okada H, et al., AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene. Oncogene. 1998 Nov 5;17(18):2287-93
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory