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Targeted Allele Detail
Symbol: Ncf1tm1Shl
Name: neutrophil cytosolic factor 1; targeted mutation 1, Steven M Holland
MGI ID: MGI:1934143
Synonyms: p47phox-, p47phox-, p47phox-
Gene: Ncf1  Location: Chr5:134220053-134229625 bp, - strand  Genetic Position: Chr5, 74.47 cM
Ncf1tm1Shl/Ncf1tm1Shl mice develop lethal infections and granulomatous inflammation

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:28267
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsInsertion of a neomycin resistance cassette into exon 7 disrupted the gene. The region in the human ortholog that corresponds to exon 7 is known to be necessary for gene function. (J:28267, J:103487)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ncf1 Mutation:  6 strains or lines available
Original:  J:28267 Jackson SH, et al., The p47phox mouse knock-out model of chronic granulomatous disease. J Exp Med. 1995 Sep 1;182(3):751-8
All:  83 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory