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Targeted Allele Detail
Symbol: P2rx3tm1Ckn
Name: purinergic receptor P2X, ligand-gated ion channel, 3; targeted mutation 1, Debra A Cockayne
MGI ID: MGI:1934019
Synonyms: P2X3-
Gene: P2rx3  Location: Chr2:84828927-84867806 bp, - strand  Genetic Position: Chr2, 49.45 cM
Germline Transmission:  Earliest citation of germline transmission: J:65557
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 1 was replaced with a neomycin resistance gene via homologous recombination, thus deleting the translation initiation codon. Protein product was absent from dorsal root ganglion, spinal cord, and peripheral tissues of homozygous mutant animals as shown by immunohistochemistry. (J:65557)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any P2rx3 Mutation:  15 strains or lines available
Original:  J:65557 Cockayne DA, et al., Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice. Nature. 2000 Oct 26;407(6807):1011-5
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory