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Targeted Allele Detail
Symbol: Dgat1tm1Far
Name: diacylglycerol O-acyltransferase 1; targeted mutation 1, Bob Farese
MGI ID: MGI:1934012
Gene: Dgat1  Location: Chr15:76386215-76396153 bp, - strand  Genetic Position: Chr15, 35.99 cM
Enhanced epidermal response to topical retinol treatment in Dgat1tm1Far/Dgat1tm1Far mice

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:61885
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment containing sequences encoding the carboxy-terminus of the protein was replaced by a neomycin cassette. Northern blot analysis did not detect a full length transcript produced from this allele in homozygous mice. Tissue DGAT activity was absent ot severely reduced in homozygous mice. (J:61885)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dgat1 Mutation:  25 strains or lines available
Original:  J:61885 Smith SJ, et al., Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat [see comments]. Nat Genet. 2000 May;25(1):87-90
All:  32 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory