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Targeted Allele Detail
Symbol: Bmp7tm1Kry
Name: bone morphogenetic protein 7; targeted mutation 1, Gerard Karsenty
MGI ID: MGI:1934010
Synonyms: Bmp7-, Bmp7delta, bmp-7m1
Gene: Bmp7  Location: Chr2:172868012-172940321 bp, - strand  Genetic Position: Chr2, 95.54 cM
Germline Transmission:  Earliest citation of germline transmission: J:30056
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn hypoxanthine phosphoribosyl transferase (hprt) minigene replaced a genomic fragment containing exons 6 and 7. These sequences encode the mature domain of the processed polypeptide. Northern blot analysis revealed that no stable transcript was produced from this allele in homozygous mice. (J:30056)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bmp7 Mutation:  16 strains or lines available
Original:  J:30056 Luo G, et al., BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev. 1995 Nov 15;9(22):2808-20
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory