Bmp7^tm1Kry
Targeted Allele Detail

Summary

• Symbol: Bmp7^tm1Kry
• Name: bone morphogenetic protein 7; targeted mutation 1, Gerard Karsenty
• MGI ID: MGI:1934010
• Synonyms: Bmp7^-, Bmp7^delta, bmp-7^m1
• Gene: Bmp7 Location: Chr2:172709805-172782114 bp, - strand Genetic Position: Chr2, 95.54 cM
• Alliance: Bmp7^tm1Kry page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:30056
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An hypoxanthine phosphoribosyl transferase (hprt) minigene replaced a genomic fragment containing exons 6 and 7. These sequences encode the mature domain of the processed polypeptide. Northern blot analysis revealed that no stable transcript was produced from this allele in homozygous mice. (J:30056)

Expression

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bmp7 Mutation: 37 strains or lines available

References

• Original: J:30056 Luo G, et al., BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev. 1995 Nov 15;9(22):2808-20
• All: 13 reference(s)