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Cln3tm1Nbm
Targeted Allele Detail
Nomenclature
Symbol: Cln3tm1Nbm
Name: ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease); targeted mutation 1, Robert L Nussbaum
MGI ID: MGI:1933976
Synonyms: Cln3-, Cln-3deltaex1-6
Gene: Cln3  Location: Chr7:126571207-126585817 bp, - strand  Genetic Position: Chr7, 69.16 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:58230
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2-6 and most of exon 1, including the start codon of the Cln3 gene were replaced with a neomycin resistance gene transcribed in the reverse orientation from a mouse PGK promoter. (J:55232, J:58230)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Cln3 Mutation:  24 strains or lines available
References
Original:  J:58230 Mitchison HM, et al., Targeted disruption of the Cln3 gene provides a mouse model for Batten disease. Neurobiol Dis. 1999 Oct;6(5):321-34
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/11/2018
MGI 6.12
The Jackson Laboratory