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Targeted Allele Detail
Symbol: Ntrk3tm1Par
Name: neurotrophic tyrosine kinase, receptor, type 3; targeted mutation 1, Luis F Parada
MGI ID: MGI:1933975
Synonyms: trkC -, trkCE-
Gene: Ntrk3  Location: Chr7:78179986-78581034 bp, - strand  Genetic Position: Chr7, 44.01 cM
Malformations in cardiogenesis of Ntrk3tm1Par/Ntrk3tm1Par mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:45083
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsInsertion of a neomycin cassette into the first coding exon of the gene. No protein was detectable in Western blots of lysates from newborn homozygous mutant mouse brains. (J:45083)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 20 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ntrk3 Mutation:  9 strains or lines available
Original:  J:45083 Tessarollo L, et al., Targeted deletion of all isoforms of the trkC gene suggests the use of alternate receptors by its ligand neurotrophin-3 in neuronal development and implicates trkC in normal cardiogenesis. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14776-81
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory