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Targeted Allele Detail
Symbol: Ntf5tm1Par
Name: neurotrophin 5; targeted mutation 1, Luis F Parada
MGI ID: MGI:1933845
Synonyms: NT-4 -, NT-4/5 KO
Gene: Ntf5  Location: Chr7:45413695-45417179 bp, + strand  Genetic Position: Chr7, 29.3 cM
Germline Transmission:  Earliest citation of germline transmission: J:60927
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neomycin resistance cassette replaced the entire coding region. In situ studies confirmed that no detectable transcript was expressed in DRG neurons of homozygous mutant neonates. (J:60927)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ntf5 Mutation:  8 strains or lines available
Original:  J:60927 Liebl DJ, et al., Loss of brain-derived neurotrophic factor-dependent neural crest-derived sensory neurons in neurotrophin-4 mutant mice. Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2297-302
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory