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Ntf5tm1Par
Targeted Allele Detail
Summary
Symbol: Ntf5tm1Par
Name: neurotrophin 5; targeted mutation 1, Luis F Parada
MGI ID: MGI:1933845
Synonyms: NT-4 -, NT-4/5 KO
Gene: Ntf5  Location: Chr7:45063119-45066603 bp, + strand  Genetic Position: Chr7, 29.3 cM
Alliance: Ntf5tm1Par page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60927
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neomycin resistance cassette replaced the entire coding region. In situ studies confirmed that no detectable transcript was expressed in DRG neurons of homozygous mutant neonates. (J:60927)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ntf5 Mutation:  12 strains or lines available
References
Original:  J:60927 Liebl DJ, et al., Loss of brain-derived neurotrophic factor-dependent neural crest-derived sensory neurons in neurotrophin-4 mutant mice. Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2297-302
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory