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Targeted Allele Detail
Symbol: Cdkn2ctm1Bbd
Name: cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4); targeted mutation 1, Mariano Barbacid
MGI ID: MGI:1933761
Synonyms: Ink4c-, p18INK4c-
Gene: Cdkn2c  Location: Chr4:109660876-109667189 bp, - strand  Genetic Position: Chr4, 51.32 cM
Germline Transmission:  Earliest citation of germline transmission: J:63299
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 2, encoding amino acid residues 43-168, was replaced by a neomycin cassette. No protein was detected in Western blots of lysates derived from tissues of 3 month old homozygous mutant mice. (J:63299)
Inheritance:    Recessive
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdkn2c Mutation:  3 strains or lines available
Original:  J:63299 Latres E, et al., Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis. EMBO J. 2000 Jul 3;19(13):3496-506
All:  20 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory