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Targeted Allele Detail
Symbol: Cdkn2btm1Bbd
Name: cyclin dependent kinase inhibitor 2B; targeted mutation 1, Mariano Barbacid
MGI ID: MGI:1933760
Synonyms: p15INK4b-
Gene: Cdkn2b  Location: Chr4:89306299-89311039 bp, - strand  Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
Germline Transmission:  Earliest citation of germline transmission: J:63299
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 2, encoding amino acids 44-130, was replaced by a neomycin cassette. No protein was detectable in Western blots of immunoprecipitates of MEF lysates derived from homozygous mutant embryos. (J:63299)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdkn2b Mutation:  2 strains or lines available
Original:  J:63299 Latres E, et al., Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis. EMBO J. 2000 Jul 3;19(13):3496-506
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory