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Cdkn2btm1Bbd
Targeted Allele Detail
Nomenclature
Symbol: Cdkn2btm1Bbd
Name: cyclin dependent kinase inhibitor 2B; targeted mutation 1, Mariano Barbacid
MGI ID: MGI:1933760
Synonyms: p15INK4b-
Gene: Cdkn2b  Location: Chr4:89306289-89311032 bp, - strand  Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63299
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2, encoding amino acids 44-130, was replaced by a neomycin cassette. No protein was detectable in Western blots of immunoprecipitates of MEF lysates derived from homozygous mutant embryos. (J:63299)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdkn2b Mutation:  1 strain or line available
References
Original:  J:63299 Latres E, et al., Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis. EMBO J. 2000 Jul 3;19(13):3496-506
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/10/2018
MGI 6.12
The Jackson Laboratory