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Cbfbtm1Tno
Targeted Allele Detail
Nomenclature
Symbol: Cbfbtm1Tno
Name: core binding factor beta; targeted mutation 1, Tetsuo Noda
MGI ID: MGI:1933624
Synonyms: PEBP2beta/CBFbeta (-), Pebpb2-
Gene: Cbfb  Location: Chr8:105170674-105217989 bp, + strand  Genetic Position: Chr8, 53.04 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:40963
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced exon 1, which contains the translation start site and the sequences encoding the first 26 amino acids of the protein. RT-PCR analysis on RNA derived from homozygous embryos demonstrated that no detectable transcript is produced from this allele, and western blot analysis on embryo extracts derived from homozygous mice confirmed that no stable protein is made. (J:40963)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 58 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cbfb Mutation:  27 strains or lines available
References
Original:  J:40963 Niki M, et al., Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor. Proc Natl Acad Sci U S A. 1997 May 27;94(11):5697-702
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory