Pou5f1tm1Cgre
Targeted Allele Detail
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Symbol: |
Pou5f1tm1Cgre |
Name: |
POU domain, class 5, transcription factor 1; targeted mutation 1, Centre for Genome Research |
MGI ID: |
MGI:1933381 |
Synonyms: |
Oct4- |
Gene: |
Pou5f1 Location: Chr17:35816929-35821674 bp, + strand Genetic Position: Chr17, 18.69 cM
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Alliance: |
Pou5f1tm1Cgre page
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Germline Transmission: |
Earliest citation of germline transmission:
J:51139
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Parent Cell Line: |
CGR8 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: An internal ribosome entry site-lacZ-neomycin resistance cassette (IRES-beta-geo) replaced sequences in exons 2-5 encoding the two DNA binding domains and the carboxy terminal transactivation site. Immunostaining did not detect wild-type protein in 3 of 15 2.5 day morulae from an intercross of heterozygous mutant animals.
(J:51139)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pou5f1 Mutation: |
82 strains or lines available
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Original: |
J:51139 Nichols J, et al., Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell. 1998 Oct 30;95(3):379-91 |
All: |
5 reference(s) |
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