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Alox12tm1Fun
Targeted Allele Detail
Nomenclature
Symbol: Alox12tm1Fun
Name: arachidonate 12-lipoxygenase; targeted mutation 1, Colin Funk
MGI ID: MGI:1932927
Synonyms: 12/15LO KO, P-12LO-
Gene: Alox12  Location: Chr11:70241457-70255353 bp, - strand  Genetic Position: Chr11, 42.99 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:46896
Parent Cell Line:  D3H (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced exon 8. Western blot analysis did not detect the encoded protein in homozygous mutant platelets. (J:46896)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Alox12 Mutation:  16 strains or lines available
References
Original:  J:46896 Johnson EN, et al., Increased platelet sensitivity to ADP in mice lacking platelet-type 12-lipoxygenase. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3100-5
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory