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Zp2tm1Dean
Targeted Allele Detail
Nomenclature
Symbol: Zp2tm1Dean
Name: zona pellucida glycoprotein 2; targeted mutation 1, Jurrien Dean
MGI ID: MGI:1932591
Synonyms: Zp2tm, Zp2tm1Nih, Zp2tm2Nih
Gene: Zp2  Location: Chr7:120126772-120145291 bp, - strand  Genetic Position: Chr7, 64.38 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:67817
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPart of exon 1 and exon 2 were replaced by a neomycin cassette. Absence of the protein was confirmed by immunohistochemistry on ovarian sections of mutant female mice. (J:67817)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Zp2 Mutation:  32 strains or lines available
References
Original:  J:67817 Rankin TL, et al., Defective zonae pellucidae in Zp2-null mice disrupt folliculogenesis, fertility and development. Development. 2001 Apr;128(7):1119-26
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/30/2021
MGI 6.16
The Jackson Laboratory