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Targeted Allele Detail
Symbol: Cr2tm1Hmo
Name: complement receptor 2; targeted mutation 1, Hector Molina
MGI ID: MGI:1932568
Synonyms: CD21-KO, Cr, CR1/2-, CR1/CR2-, Cr2-
Gene: Cr2  Location: Chr1:195136811-195176716 bp, - strand  Genetic Position: Chr1, 98.44 cM
Germline Transmission:  Earliest citation of germline transmission: J:35112
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neomycin resistance cassette replaced part of the first and all of the second exon encoding short consensus repeat (SCR) 14. Flow cytometry of spleen cells using three different rat antimouse CR2 monoclonal antibodies showed that homozygous mutant mice were deficient in the expression of the receptors. (J:35112)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cr2 Mutation:  36 strains or lines available
Original:  J:35112 Molina H, et al., Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2. Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3357-61
All:  34 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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