About   Help   FAQ
Targeted Allele Detail
Symbol: Ttpatm1Far
Name: tocopherol (alpha) transfer protein; targeted mutation 1, Bob Farese
MGI ID: MGI:1932559
Synonyms: alpha-TTP-KO, Ttpa-
Gene: Ttpa  Location: Chr4:20007938-20030785 bp, + strand  Genetic Position: Chr4, 7.76 cM, cytoband A3
Morphology of aortic lesions in Apoetm1Unc/Apoetm1Unc and Apoetm1Unc/Apoetm1Unc Ttpatm1Far/Ttpatm1Far mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:66419
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA lacZ-neomycin resistance cassette replaced part of the 5' untranslated region and exon 1 including the translational start codon. Immunoblot analysis of liver did not detect wild-type protein in homozygous mutant mice. (J:66419)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ttpa Mutation:  12 strains or lines available
Original:  J:66419 Terasawa Y, et al., Increased atherosclerosis in hyperlipidemic mice deficient in alpha -tocopherol transfer protein and vitamin E. Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13830-4
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory