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Targeted Allele Detail
Symbol: Ttpatm1Far
Name: tocopherol (alpha) transfer protein; targeted mutation 1, Bob Farese
MGI ID: MGI:1932559
Synonyms: alpha-TTP-KO, Ttpa-
Gene: Ttpa  Location: Chr4:20007938-20030785 bp, + strand  Genetic Position: Chr4, 7.76 cM, cytoband A3
Morphology of aortic lesions in Apoetm1Unc/Apoetm1Unc and Apoetm1Unc/Apoetm1Unc Ttpatm1Far/Ttpatm1Far mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:66419
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA lacZ-neomycin resistance cassette replaced part of the 5' untranslated region and exon 1 including the translational start codon. Immunoblot analysis of liver did not detect wild-type protein in homozygous mutant mice. (J:66419)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ttpa Mutation:  13 strains or lines available
Original:  J:66419 Terasawa Y, et al., Increased atherosclerosis in hyperlipidemic mice deficient in alpha -tocopherol transfer protein and vitamin E. Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13830-4
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory