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Foxg1tm1(cre)Skm
Targeted Allele Detail
Nomenclature
Symbol: Foxg1tm1(cre)Skm
Name: forkhead box G1; targeted mutation 1, Susan K McConnell
MGI ID: MGI:1932522
Synonyms: BF1-cre, Foxg1-, Foxg1Cre, Foxg1-Cre, Foxg1:Cre, FoxG1Cre, Foxg1KiCre, TgH(Foxg1-Cre)1Skm
Gene: Foxg1  Location: Chr12:49382660-49386861 bp, + strand  Genetic Position: Chr12, 21.78 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62916
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsMost of the coding region was replaced with a cre gene and a neomycin cassette. The cre gene sequence was fused in-frame following the first 13 codons of the gene. The endogenous promoter is active in telencephalon, anterior optic vesicle, otic vesicle, facial and head ectoderm, olfactory epithelium, mid-hindbrain junction and pharyngeal pouches. (J:62916)
Inheritance:    Recessive
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Foxg1     Summary of all recombinase alleles driven by Foxg1. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 37 assay results
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Foxg1 Mutation:  14 strains or lines available
Notes
Cre mediated recombination was demonstrated in 3 reporter mouse lines in the following tissues: telencephalon, anterior optic vesicle, otic vesicle, facial and head ectoderm, olfactory epithelium, mid-hindbrain junction, and pharyngeal pouches.
References
Original:  J:62916 Hebert JM, et al., Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures. Dev Biol. 2000 Jun 15;222(2):296-306
All:  202 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory