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Targeted Allele Detail
Symbol: Foxg1tm1(cre)Skm
Name: forkhead box G1; targeted mutation 1, Susan K McConnell
MGI ID: MGI:1932522
Synonyms: BF1-cre, Foxg1-, Foxg1Cre, Foxg1-Cre, Foxg1:Cre, FoxG1Cre, Foxg1KiCre, TgH(Foxg1-Cre)1Skm
Gene: Foxg1  Location: Chr12:49382883-49386867 bp, + strand  Genetic Position: Chr12, 21.78 cM
Germline Transmission:  Earliest citation of germline transmission: J:62916
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted (Null/knockout, Recombinase)
Mutations:    Insertion, Intragenic deletion
Mutation detailsMost of the coding region was replaced with a cre gene and a neomycin cassette. The cre gene sequence was fused in-frame following the first 13 codons of the gene. The endogenous promoter is active in telencephalon, anterior optic vesicle, otic vesicle, facial and head ectoderm, olfactory epithelium, mid-hindbrain junction and pharyngeal pouches. (J:62916)
Inheritance:    Recessive
 Tissue activity of this recombinase allele
Driver: Foxg1     Summary of all recombinase alleles driven by Foxg1. Comparative matrix view of recombinase activities

View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 177 assay results
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Foxg1 Mutation:  3 strains or lines available
Cre mediated recombination was demonstrated in 3 reporter mouse lines in the following tissues: telencephalon, anterior optic vesicle, otic vesicle, facial and head ectoderm, olfactory epithelium, mid-hindbrain junction, and pharyngeal pouches.
Original:  J:62916 Hebert JM, et al., Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures. Dev Biol. 2000 Jun 15;222(2):296-306
All:  238 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory