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Chemically induced Allele Detail
Symbol: CrygeAey1
Name: crystallin, gamma E; nuclear and zonular cataract
MGI ID: MGI:1932397
Gene: Cryge  Location: Chr1:65048554-65051149 bp, - strand  Genetic Position: Chr1, 32.8 cM
Strain of Origin:  C3HeB/FeJ
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsA transversion of an A at position 1 of the cDNA to a T. This results in expression from an ATG 19 bp downstream. The phase of this ORF is shifted +1 to produce a novel protein, which may interfere with the normal structural organization of the lens. (J:67888)
Inheritance:    Dominant
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cryge Mutation:  7 strains or lines available
Phenotypic Similarity to Human Syndrome: Dominant Cataracts in heterozygous and homozygous mice (J:67888)

Original:  J:68708 Hrabe de Angelis MH, et al., Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat Genet. 2000 Aug;25(4):444-7
All:  3 reference(s)

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MGI 5.21
The Jackson Laboratory