F9^tm1Dws
Targeted Allele Detail

Summary

• Symbol: F9^tm1Dws
• Name: coagulation factor IX; targeted mutation 1, Darrel W Stafford
• MGI ID: MGI:1932297
• Synonyms: factor IX-knockout, FIX(-), HB
• Gene: F9 Location: ChrX:59044824-59076119 bp, + strand Genetic Position: ChrX, 33.5 cM, cytoband A6-A7
• Alliance: F9^tm1Dws page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44497
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1, 2 and 3 are replaced by a neomycin/hprt minigene cassette. No mRNA was detected in hemizygous male mice as assayed by RT-PCR analysis. (J:44497)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any F9 Mutation: 8 strains or lines available

References

• Original: J:44497 Lin HF, et al., A coagulation factor IX-deficient mouse model for human hemophilia B. Blood. 1997 Nov 15;90(10):3962-6
• All: 31 reference(s)