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F9tm1Dws
Targeted Allele Detail
Nomenclature
Symbol: F9tm1Dws
Name: coagulation factor IX; targeted mutation 1, Darrel W Stafford
MGI ID: MGI:1932297
Synonyms: factor IX-knockout, FIX(-), HB
Gene: F9  Location: ChrX:59044824-59076119 bp, + strand  Genetic Position: ChrX, 33.5 cM, cytoband A6-A7
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:44497
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1, 2 and 3 are replaced by a neomycin/hprt minigene cassette. No mRNA was detected in hemizygous male mice as assayed by RT-PCR analysis. (J:44497)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any F9 Mutation:  6 strains or lines available
References
Original:  J:44497 Lin HF, et al., A coagulation factor IX-deficient mouse model for human hemophilia B. Blood. 1997 Nov 15;90(10):3962-6
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory