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Mmp9tm1Tvu
Targeted Allele Detail
Nomenclature
Symbol: Mmp9tm1Tvu
Name: matrix metallopeptidase 9; targeted mutation 1, Thiennu H Vu
MGI ID: MGI:1932294
Synonyms: Gelatinase B-Null, GelB-, Mmp9-, MMP-9-, MMP9-, MMP-9KO, MMP-9 KO
Gene: Mmp9  Location: Chr2:164940780-164955850 bp, + strand  Genetic Position: Chr2, 85.27 cM, cytoband H1-H2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47297
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPart of exon 2 and all of intron 2 were replaced with a cassette containing the neomycin resistance gene driven by a PGK promoter. (J:47297)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 22 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Mmp9 Mutation:  28 strains or lines available
Notes
ES cell line = ZW4.
References
Original:  J:47297 Vu TH, et al., MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell. 1998 May 1;93(3):411-22
All:  214 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory