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Nkx2-2tm1Jlr
Targeted Allele Detail
Nomenclature
Symbol: Nkx2-2tm1Jlr
Name: NK2 homeobox 2; targeted mutation 1, John L Rubenstein
MGI ID: MGI:1932100
Synonyms: Nkx2.2-
Gene: Nkx2-2  Location: Chr2:147177546-147194243 bp, - strand  Genetic Position: Chr2, 72.63 cM, cytoband H
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:48576
Parent Cell Line:  JM-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsInsertion of a PGK-neomycin resistance cassette replaced exons 1 and 2. Immunohistochemical studies of pancreas and CNS did not detect protein in homozygous mutant mice. (J:48576)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 8 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkx2-2 Mutation:  4 strains or lines available
References
Original:  J:48576 Sussel L, et al., Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development. 1998 Jun;125(12):2213-21
All:  40 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory