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Spp1tm1Blh
Targeted Allele Detail
Nomenclature
Symbol: Spp1tm1Blh
Name: secreted phosphoprotein 1; targeted mutation 1, Brigid L Hogan
MGI ID: MGI:1932083
Synonyms: eta1, Eta-1, Opn-, OPN-, OPN-KO
Gene: Spp1  Location: Chr5:104435118-104441050 bp, + strand  Genetic Position: Chr5, 50.68 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:46863
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK neomycin resistance cassette replaced exons 4-7 of the Spp1 gene. No Spp1 transcript was detected by RT-PCR in embryonic fibroblasts or adult kidney from homozygous mutant animals. Spp1 transcript was not detected in homozygous mutant animals by in situ hybridization. Immunohistochemistry studies of adult kidney and bone did not detect protein in homozygous mutant mice. (J:46863)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Spp1 Mutation:  16 strains or lines available
References
Original:  J:46863 Liaw L, et al., Altered wound healing in mice lacking a functional osteopontin gene (spp1). J Clin Invest. 1998 Apr 1;101(7):1468-78
All:  71 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory