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Vimtm1Cba
Targeted Allele Detail
Nomenclature
Symbol: Vimtm1Cba
Name: vimentin; targeted mutation 1, Charles Babinet
MGI ID: MGI:1931877
Synonyms: Vim-, Vim1
Gene: Vim  Location: Chr2:13573927-13582826 bp, + strand  Genetic Position: Chr2, 10.04 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:21588
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsExon 1 of the Vim gene was disrupted by insertion of a LacZ neomycin resistance cassette. Northern analysis of organs from homozygous mutant animals did not detect Vim transcript. Western analysis, immunofluorescence microsopy, and immunohistochemical studies did not detect VIM protein in tissues of homozygous mutant mice. The endogenous Vim promoter controls expression of beta-galactosidase in the targeted allele. (J:21588)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 8 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Vim Mutation:  7 strains or lines available
References
Original:  J:21588 Colucci-Guyon E, et al., Mice lacking vimentin develop and reproduce without an obvious phenotype. Cell. 1994 Nov 18;79(4):679-94
All:  41 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory