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Smarcb1tm1Sho
Targeted Allele Detail
Nomenclature
Symbol: Smarcb1tm1Sho
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1; targeted mutation 1, Stuart Orkin
MGI ID: MGI:1931875
Synonyms: Snf5-
Gene: Smarcb1  Location: Chr10:75896769-75921617 bp, - strand  Genetic Position: Chr10, 38.61 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66417
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A neomycin resistance cassette replaced exon 1 of the Smarcb1 gene, including the initiation site. (J:66417)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smarcb1 Mutation:  14 strains or lines available
References
Original:  J:66417 Roberts CW, et al., Haploinsufficiency of snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice. Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13796-800
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory