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Targeted Allele Detail
Symbol: Ncoa3tm1Rsd
Name: nuclear receptor coactivator 3; targeted mutation 1, Michael G Rosenfeld
MGI ID: MGI:1931861
Synonyms: p/CIP-
Gene: Ncoa3  Location: Chr2:165992636-166071470 bp, + strand  Genetic Position: Chr2, 86.22 cM, cytoband H2-H4
Germline Transmission:  Earliest citation of germline transmission: J:66454
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced sequences encoding the CREB-binding protein (CBP) binding domain and much of the nuclear receptor interaction domain. Immunoblot analysis of kidney extract did not detect NCOA3 in homozygous mutant animals. (J:66454)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ncoa3 Mutation:  231 strains or lines available
Original:  J:66454 Wang Z, et al., Regulation of somatic growth by the p160 coactivator p/CIP. Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13549-54
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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