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Targeted Allele Detail
Symbol: Ncoa3tm1Jxu
Name: nuclear receptor coactivator 3; targeted mutation 1, Jianming Xu
MGI ID: MGI:1931860
Synonyms: AIB1-, SRC-3-
Gene: Ncoa3  Location: Chr2:165992636-166073242 bp, + strand  Genetic Position: Chr2, 86.22 cM, cytoband H2-H4
Alveolar formation is reduced in the Ncoa3tm1Jxu/Ncoa3tm1Jxu mammary gland.

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:62724
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA TGK-neomycin resistance cassette replaced sequences spanning exon 2 through exon 13. The cassette introduced a lacZ sequence in frame with the endogenous promoter. The authors predict that the targeted allele would not produce a functional protein, but would produce a beta-galactosidase fusion protein controlled by the endogenous promoter. Western analysis did not detect wild-type protein in lactating mammary glands of homozygous mutant mice. (J:62724)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 14 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ncoa3 Mutation:  173 strains or lines available
Original:  J:62724 Xu J, et al., The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6379-84
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
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