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Hoxa1tm2Ipc
Targeted Allele Detail
Nomenclature
Symbol: Hoxa1tm2Ipc
Name: homeobox A1; targeted mutation 2, Pierre Chambon
MGI ID: MGI:1931847
Synonyms: Hoxa13'RARE, Hoxa1deltaRARE-(L)
Gene: Hoxa1  Location: Chr6:52155590-52158317 bp, - strand  Genetic Position: Chr6, 25.4 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:38388
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details18 bps of the 3'RARE were replaced by a Sal1 restriction enzyme site. A lox-P flanked neomycin cassette was inserted into the Sal1 site and was later removed via Cre-mediated recombination in the final allele. (J:38388)
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 53 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxa1 Mutation:  7 strains or lines available
References
Original:  J:38388 Dupe V, et al., In vivo functional analysis of the Hoxa-1 3' retinoic acid response element (3'RARE). Development. 1997 Jan;124(2):399-410
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory