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Atp6v0ctm1Hka
Targeted Allele Detail
Nomenclature
Symbol: Atp6v0ctm1Hka
Name: ATPase, H+ transporting, lysosomal V0 subunit C; targeted mutation 1, Hiroshi Kanazawa
MGI ID: MGI:1931846
Synonyms: Atp6ltm1Hka, PL16-
Gene: Atp6v0c  Location: Chr17:24163866-24169702 bp, - strand  Genetic Position: Chr17, 12.29 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:58416
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced the first translation initiation site in exon 1. The mRNA levels in tissues of heterozygous mutant animals are estimated to be about one half of wild-type levels. (J:58416)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atp6v0c Mutation:  7 strains or lines available
References
Original:  J:58416 Inoue H, et al., Targeted disruption of the gene encoding the proteolipid subunit of mouse vacuolar H(+)-ATPase leads to early embryonic lethality. Biochim Biophys Acta. 1999 Nov 10;1413(3):130-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory