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Targeted Allele Detail
Symbol: Atp6v0ctm1Hka
Name: ATPase, H+ transporting, lysosomal V0 subunit C; targeted mutation 1, Hiroshi Kanazawa
MGI ID: MGI:1931846
Synonyms: Atp6ltm1Hka, PL16-
Gene: Atp6v0c  Location: Chr17:24163866-24169702 bp, - strand  Genetic Position: Chr17, 12.29 cM
Germline Transmission:  Earliest citation of germline transmission: J:58416
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced the first translation initiation site in exon 1. The mRNA levels in tissues of heterozygous mutant animals are estimated to be about one half of wild-type levels. (J:58416)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atp6v0c Mutation:  7 strains or lines available
Original:  J:58416 Inoue H, et al., Targeted disruption of the gene encoding the proteolipid subunit of mouse vacuolar H(+)-ATPase leads to early embryonic lethality. Biochim Biophys Acta. 1999 Nov 10;1413(3):130-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
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