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Jag1Slalom
Chemically induced Allele Detail
Nomenclature
Symbol: Jag1Slalom
Name: jagged 1; slalom
MGI ID: MGI:1931798
Synonyms: Gena158, Gena 158, slalom, Slm
Gene: Jag1  Location: Chr2:137081451-137116520 bp, - strand  Genetic Position: Chr2, 67.73 cM
Mutation
origin
Strain of Origin:  BALB/cAnNCrl
Project Collection: Harwell ENU Mutagenesis
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsA C to T missense mutation causes a proline to serine change at conserved codon 269 in the second epidermal growth factor (EGF)-like repeat. (J:63716, J:67728)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Jag1 Mutation:  8 strains or lines available
Notes
This mutation was induced by ENU treatment of a BALB/cAnNCrl male mouse that was then mated with C3H/HeNCrl females. Mapping of the dominant mutation was achieved using IVF-generated backcross progeny of the founder male x C3H females. (J:63816, J:67728)
References
Original:  J:67728 Tsai H, et al., The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti. Hum Mol Genet. 2001 Mar 1;10(5):507-12
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory